Emergent trends (or emergence) is a term used to describe interconnection and that the whole « is more than just the sum of its parts ». The interaction of hormones and neurotransmitters takes a form that then tells us a little something about what is going on by way of symptoms. More and more, science is becoming more sophisticated in showing us that we are a whole with a connection between our mood, psychology, stress response, hormones, and immune system. A new study tested what symptoms tell us whether our hormonal system is being over-activated based on the adrenal or thyroid axis. Interesting to note that this study was held in China, where Traditional Chinese Medicine would take into consideration the different manifestations of depression, or stress responses, based on different organ systems. It is no wonder that what was discovered many years ago, could be the same as today…. just another way of looking at it.
Symptoms are a sign of an imbalance, and if they continue to persist, will intensify unless you take an action to make a change.
Alterations in hypothalamic-pituitary-adrenal/thyroid (HPA/HPT) axes correlated with the clinical manifestations of depression.
Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China.
The alterations of hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-thyroid (HPT) axes are important neuroendocrine abnormalities in depression. We aimed to identify some potential associations between these alterations and the clinical manifestations of depression in a sample of Chinese origin. 565 depressed patients of Chinese Han region were collected and seven kinds of hormones in HPA and HPT axes were detected. A 17-item Hamilton Depression Rating Scale (HAMD-17) and a 14-item Hamilton Anxiety Rating Scale (HAMA-14) were used to evaluate the baseline condition of each patient. 519 patients were enrolled into analysis. The patients with dysfunction of HPA axis had susceptibility to agitation symptoms (HAMD9 item) and cognitive disorders (HAMD2, 3 and 9 items), while those with normal function of HPA axis had susceptibility to shallow sleep (HAMD5 item). The patients with dysfunction of HPT axis had susceptibility to difficulty in falling asleep (HAMD4 item), weight loss (HAMD16 item) and gastrointestinal symptoms (HAMD12 item). Besides, the patients with dysfunctions of both HPA and HPT axes showed remarkable retardation symptoms (HAMD8 item). These findings might provide some evidences for the clinical subgrouping and management individualization of depressed patients according to the neuroendocrine alterations.